What is systemic mastocytosis?

DEAR DR. GOTT: My 27-year-old daughter has been diagnosed with system mastocytosis. We are aware that there is no cure but would like to know what you can tell us about the disorder. Do you know of any effective treatments? We are very concerned for her health and future. Is it hereditary? Any help and information would be appreciated.

DEAR READER: Systemic mastocytosis (SM) is considered to be an “orphan disease” meaning it is rare and affects a very small number of people. It is an accumulation of mast cells in more than one part of the body. Mast cells are made in the bone marrow, are distributed throughout the body and are though to fight infection, respond to allergic substances, and repair damaged tissue. It is usually diagnosed in adults although children may also be affected.
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