Q: On February 12th I began taking Terbinafine HCL (250 mg tablet once daily) prescribed for a fingernail fungus that I have had for years.
After four weeks of treatment, blood tests determine the medicine was not adversely affecting my liver; therefore, my doctor authorized a refill. I stopped taking the medication on March 19th because I became alarmingly aware that it had seriously affected my ability to taste – this, along with dry mouth and throat. Although it has been two weeks since I stopped taking Terbinafine, I have yet to regain my sense of taste and the dry mouth and throat persist. All food consumption is akin to what can only be described as eating cardboard or unadulterated wax. I have to force myself to eat anything and have gone from 120 pounds to 115 pounds.
Please share your thoughts and knowledge regarding this awful side effect. Can you tell me if you know of other individuals who have taken this medication and were similarly affected. What percentage found it to be permanent.
A: Terbinafine is an anti-fungal that prevents fungus from growing on the skin. The topical form is used to treat ringworm infections, athlete’s foot, jock itch and other skin infections, while Terbinafine Hydrochloride is prescribed to treat fungal infections of toenails and fingernails. Results may not be apparent for several months, essentially because it takes that long for new nails to grow. The topical form available in cream or gel solution is 1%; the oral form of the drug comes in 250 mg tablets. Oral granules are available in 125 and 187.5 mg strengths. Dosing is commonly one tablet daily for six weeks for fingernails, 12 weeks for toenails; with topical applications, once daily for ringworm or jock itch and twice daily for athlete’s foot for a week. The medication should not be discontinued abruptly.
Side effects may cause body aches, flu-like symptoms, fever, chills, joint pain, diarrhea, swollen glands, a butterfly-shaped rash over cheeks and nose, hives, difficulty breathing,weight loss because of a taste disturbance, loss of smell, hepatic failure, and more. Because of the potential for liver failure (that can occur with countless prescription drugs), your physician correctly had you tested. Taste disturbances are typically noticed five to eight weeks following the initiation of therapy, returning to normal within five weeks of stopping the drug. Many people on Terbinafine do not experience serious side effects. When they do occur, a physician should be advised.
Alcohol consumption should be limited and for some, a sun sensitivity might occur. Therefore, prolonged exposure to the sun’s rays when out of doors, the use of tanning booths and sunlamps should be avoided. Because the medication passes into breast milk, it should be not be prescribed for women who are nursing. Individuals with a weakened immune system, lupus, psoriasis, food or medication allergies, on herbals or dietary supplements should advise their physician of such prior to initiating Terbinafine.
There are numerous medications available over-the-counter without what appears to be too many potential side effects. For example, Miranel that contains tea tree oil, Iodides Tincture (decolorized iodine), Mercuroclear, medicated chest rubs, and cider vinegar have all be used successfully to treat nail fungus. To the best of my knowledge, all the products but the last are available at Wal*Mart and other large chains, while cider vinegar can be purchased at your local grocery store.
My guess is that your residual symptoms should dissipate shortly, at least I certainly hope so. The reported incidence of people similarly affected is 3%, but your word is now out. Topical medications are not as effective as are those taken by mouth but there are other drugs such as the nail lacquer amorolofine that has gained some recent popularity. Still other treatment includes surgical removal of the nail. If other readers choose to share their experiences, pro or con, I will do a follow-up in the near future.
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