DEAR DR. GOTT: I get severe leg cramps when I use Benadryl. Is it because I get dry mouth from the medication?
DEAR READER: There are a number of different Benadryl products on the market, each containing different inactive ingredients. And, as I have reported on countless occasions, all medications can carry side effects. As you have discovered, a common one in many Benadryl products is dry mouth. Furthermore, diphenhydramine/ibuprofen can cause numbness of an arm or leg and unusual joint or muscle pain.
Consider a trial without this medication. If your symptoms stop, you will have the answer. If you feel you need an antihistamine, speak with your physician regarding a substitution.