Q: I’ve recently been diagnosed with Parkinson’s and put on Levadopa. You recently said that Levodopa can cause uric acid levels in the blood to rise. My question is, what other side effects do I have to be on the lookout for with this medication.
Thank you kindly for your reply. I look forward to learning more each day from you.
A: Levodopa was designed to control the symptoms of Parkinson’s disease by helping to reduce tremor, stiffness and balance, while working to improve muscle control and balance. This drug is the most effective medication known for the treatment of the disorder, as a natural chemical that is converted to dopamine in the brain. When combined with carbidopa the two protect the levodopa from converting to dopamine outside the brain too quickly, thus providing better results. While Levodopa does not slow the progression of the disease, it does improve muscle movement and delays disability. However, the majority of those individuals will develop complications with long-term use after five to ten years. Those complications include a decrease in motor skills as being most troublesome.
Common side effects that may occur include a loss of appetite, dry mouth, abdominal pain, nightmares, increased flatulence, and more. Patients prescribed the drug or their caregivers are also advised to contact a physician if a worsening tremor, dizziness, dysphagia (difficulties swallowing), anxiety, hallucinations, gait abnormalities, nausea, vomiting or other symptoms present that were not as noticeable prior to the start of the medication.
It has been determined that Levodopa does control symptoms better than dopamine agonists, with fewer side effects reported in most patients. However, researchers are becoming more and more concerned about the drug’s relation to motor fluctuations, causing them to lean toward treatment with dopamine agonists, particularly in patients under the age of 60 when using monotherapy; however, it is common practice to add a second medication when symptoms worsen. Impulse control issues on the drug may include uncontrollable binge eating, excessive gambling, and modifications in sexual behavior. Those at risk for issues of impulse control can be seen in smokers, younger men and women rather than older individuals, and those with a family history of out-of-control gambling. As motor skills fluctuate and become more severe, it may be necessary to add another type of drug to the Levodopa treatment.
Some readers may be unaware that Parkinson’s disease is a progressive neurodegenerative disorder with tremor probably being the most common symptom, followed by rigidity, a vacant stare, gait abnormality, and slowing of movements. Handwriting may become pinched and unreadable, posture may become stooped, the fingers may repeat a “pill-rolling” movement, and the patient may shuffle his or her feet when walking.
So, as we usually advise in health and illness, eat well-balanced meals that contain fresh fruits, vegetables and whole grains. If you do add a fiber supplement to your diet introduce it gradually and add more fluids because it may exacerbate any problems with constipation. Make sure your caregivers (present or future) are well-informed regarding what to expect regarding your future care. Take measures to assure your home is free of scatter rugs and extension cords that could cause you to lose your balance and make it as safe as possible.
Other readers who are interested in related information can order Dr. Gott’s Health Report “Parkinson’s Disease” by sending a self-addressed, stamped number 10 envelope a $2 US check or money order to Peter H. Gott, MD Health Report, PO Box 433, Lakeville, CT 06039. Be sure to mention the title or print an order form from www.AskDrGottMD.com.
